PDCD1 and colorectal carcinoma: For CRC, two PD-1-blocking antibodies, pembrolizumab and nivolumab, which are already approved by the Food and Drug Administration (FDA), have shown efficacy in patients with mCRC(metastatic colorectal cancer) that are mismatch-repair-deficient and have high microsatellite instability (dMMR–MSI-H).