Kig C showed that siRNA-mediated loss of MELK expression in glioblastoma cells caused a G1/S phase cell cycle arrest accompanied by cell death or a senescence-like phenotype, which implied that MELK inhibitors hold great potential for the treatment of glioblastomas alone or in combination with DNA-damaging therapies (Kig et al., 2017). The gene discussed is MELK; the disease is glioblastoma.