PrD infections are characterized by transmissibility, progressive neurological deficits caused by the accumulation of and aggregation of a misfolded “scrapie” isoform (PrPSc) from the native cellular prion protein (PrPc); and the rapid development of a progressive systemic inflammation very similar in nature to AD (Holmes et al., 2010; Ayers et al., 2020). The gene discussed is PRNP; the disease is Alzheimer disease.