The development of ACE inhibitors (ACEi), and later of AT1R blockers (ARBs), revolutionized the therapeutic approach to kidney and heart diseases (65–68), where both groups of RAAS blockers attenuate cardiac and renal remodeling and slow down the progression of HF (69–72) and chronic kidney disease (CKD) (73–75). The gene discussed is AGTR1; the disease is chronic kidney disease.