This non-osmotic release of ADH is largely responsible for hyponatremia, a clinically important complication of heart failure, as ADH stimulates V2 receptors (V2) along increased aquaporin-2 AQP-2 water channel density in the apical side of epithelial cells in the collecting duct, ensuing water retention and eventually hyponatremia. The gene discussed is AQP2; the disease is Hyponatremia.