SLC5A2 and hydrops fetalis: At the renal level, SGLT2 inhibitors exert cardiorenal protection beyond these effects, where their natriuretic action due to inhibition of SGLT2 at the proximal tubule and increased sodium to macula densa activates tubuleoglomerular feedback (TGF) as evident by afferent arteriole vasoconstriction, thus preserving renal function as well as improve renal outcomes observed in patients with HF (268, 274).