There were considerable decreases in fat mass and a decrease of approximately 50% in self-reported levels of fatigue and depression. Diet improved MS QoL physical health and mental health composite scores. The scores on the EDSS, the 6-minute walk, and the Nine-Hole Peg Test improved significantly. On the KD, serum leptin was lower and adiponectin was greater. This evidence concerns the gene ADIPOQ and major depressive disorder.