Estrogen has been shown to increase the synthesis, release, re-uptake, and turnover of DA [73], prevent memory impairment by inhibiting NF-κB activity to modulate neurogenic inflammation [74], and improve mitochondrial damage and restore the activity of antioxidant enzymes [75], thereby reducing the risk of PD and improving symptoms of disorders with control deficits [76, 77]. The gene discussed is NFKB1; the disease is memory impairment.