Lu et al. systematically identified FRGs TFRC, ATG5, ENPP2, SCP2, MAPK1, and PRKAA1 as valuable genes for predicting the prognosis of ESCC, among which SCP2, MAPK1, and PRKAA1 were identified as independent prognostic genes (Lu T. et al., 2021). This evidence concerns the gene SCP2 and esophageal squamous cell carcinoma.