On this basis, the researcher selected SLC38A1 with noticeable expression difference to further explore its influence on the proliferation and migration of ESCC cells and finally concluded that SLC38A1 promoted the proliferation and migration of ESCC cells (Song et al., 2021); Ye et al. identified SRC, FADS2, GLUD1, POLG, ANO6, SLC2A6, PTGS2, ALOXE3, etc. (Ye et al., 2021); Zhao et al. identified six FRGs with prognostic value in 112 ESCC samples (Zhao M. et al., 2022). This evidence concerns the gene GLUD1 and esophageal squamous cell carcinoma.