A functional enrichment analysis of these proteins revealed that T cells infiltrating GBM are involved in multiple signal transduction pathways (e.g., PI3K/AKT, VEGF, PDGF, FGFR1, MAPK), whereas those from healthy PB are engaged in more steady-state functions such as mRNA splicing, showing the influence of the (tumoral) microenvironment in their cell proteomes. This evidence concerns the gene AKT1 and glioblastoma.