Although some M1 (CCL5, CD64, HLA-II molecules) and anti-tumoral (ADAM10, ADAM17, SCIN) markers were detected, the majority of GBM MAC expressed M2-linked proteins as CD14, CD36, CD163, CD204, CD206, TGFβ and HLA-II molecules (HLA-DBQ1, -DPA1, -DPB1, -DRB1, DRB3, -DRB5, CD74), together with other anti-inflammatory (FCER1G, TYROBP, SIGLEC9/10) and angiogenesis-stimulating/pro-tumoral surviving (SPP1) markers. This evidence concerns the gene HLA-DRB5 and glioblastoma.