Syndecan-1 (SDC-1), the core protein in heparan sulfate proteoglycan, is found in the endothelial glycocalyx and shed into the blood in various systemic inflammatory conditions, including trauma (7, 8), sepsis (9), acute respiratory distress syndrome (10), acute kidney injury (11) and cardiovascular disease (12, 13). This evidence concerns the gene SDC1 and cardiovascular disorder.