Arthrochalasia Ehlers-Danlos Syndrome (aEDS), also known as Ehlers-Danlos Syndrome type VII, is an autosomal dominant condition caused by heterozygous mutations in the COL1A1 and COL1A2 genes, which normally encode the pro-alpha-1 and pro-alpha-2 chains of type 1 collagen. This evidence concerns the gene COL1A1 and Ehlers-Danlos syndrome, arthrochalasia type.