Concurrently, SS-IIIA miR-23a-3p could also target PIK3R1 (Figure 7F), the expression of miR-23a-3p was specifically reduced in serum exosome of stage IIIA CRC patients, which may help to enhance the response to EGFR-targeted drugs in stage IIIA patients. Here, PIK3R1 is linked to colorectal carcinoma.