CXCL8 and colorectal carcinoma: In detail, we found that miR-23a-3p (SS-IIIA) could target CXCL8 (Figure 7F), which has been reported in several studies to play a key role in angiogenesis in CRC (84), and the specific reduction of miR-23a-3p in exosomes from stage IIIA patients may upregulate CXCL8 expression and thus promote angiogenesis.