A study from Strappazzon and colleagues found that GSK-3β phosphorylates MCL-1 to release AMBRA1, while HUWE1 promotes MCL-1 degradation in Hela cells and MCF7 breast cancer cells (32), highlighting the need for further studies to elucidate molecular mechanisms of AMBRA1 and mito-BCL-2 in mitophagy. Here, MCL1 is linked to breast cancer.