The suppressor of cytokine signaling-3 (SOCS3) is a well-known feedback inhibitor of the JAK/STAT3 pathway, and STAT3 is central in regulating the anti-tumor immune response (93–95), while AMBRA1 activates STAT3 through suppression of SOCS3 in hepatocellular carcinoma and medulloblastoma (23, 24), indicating that the regulation of tumor immunogenicity by AMBRA1 may be in a STAT3-dependent manner. This evidence concerns the gene AMBRA1 and hepatocellular carcinoma.