Interestingly, AMBRA1 plays an oncogenic role in hepatocellular carcinoma, metastatic breast cancer, and medulloblastoma, whereas AMBRA1 seems to be a tumor suppressor in colorectal cancer cell, melanoma, and squamous cell carcinoma (23, 24, 29, 33, 38, 45, 74, 75). The gene discussed is AMBRA1; the disease is squamous cell carcinoma.