PTEN and neoplasm: A study operated the foundational and differential proteomics revealed that βIII-tubulin, an isotype of β-tubulin expressed in neural tissues, which was believed to correlate with chemoresistance and poor survival, might be regulated by the PTEN/AKT axis to influence tumor proliferation and metastasis, and mspin, a tumor suppressor related to adherence was observed to increase significantly in TUBB3 knock-down NSCLC cells, accompanied by changes in cell morphology (27).