Recently, it has been reported that vascular cell adhesion molecule-1 (VCAM-1) is required for CTC/MDSCs cluster formation, thus VCAM-1 inhibition could be one of the important factors hindering CTC/MDSCs cluster formation, and developing drugs targeting VCAM-1 may reduce tumor metastasis to some extent (131). This evidence concerns the gene VCAM1 and neoplasm.