Reported that secreted protein acidic and rich in cysteine (SPARC) from MDSCs was immunosuppressive and tumor promoting in vivo in breast cancer patients, and deletion of SPARC rendered MDSCs with reduced suppressive function and restored EMT, which illustrated that the occurrence of EMT in tumor cells may depend on SPARC secreted by MDSCs (124). The gene discussed is SPARC; the disease is breast cancer.