Twenty-six HLM regulator genes with significantly higher expression levels (including EZH2, PRDM12, and KMT5C) and 25 with lower expression levels (including MECOM, PRDM11, CBX7, and so on) were found in PCa tissues compared with normal prostate tissues (P < 0.05) (Figure 2B and Table S2). Here, KMT5C is linked to posterior cortical atrophy.