Thus, we summarized the widely acknowledged HLM regulators, 51 writers (HMT), 21 erasers (HDM), and 19 readers (MLRP), and then comprehensively investigated the HLM modification patterns in PCa by assessing various clinicopathological characteristics and performing survival analysis using the TCGA-PRAD dataset. Here, OSBP2 is linked to posterior cortical atrophy.