However, while HLM regulators, such as PRDM13, PRDM1, KDM6B, CHD1, PHF23, and PRDM7, all exhibited high levels of copy number loss (> 10%), no significant downregulation (even overexpression of PRDM13) was found in the PCa of TCGA-PRAD dataset. Here, KDM6B is linked to posterior cortical atrophy.