However, while HLM regulators, such as PRDM13, PRDM1, KDM6B, CHD1, PHF23, and PRDM7, all exhibited high levels of copy number loss (> 10%), no significant downregulation (even overexpression of PRDM13) was found in the PCa of TCGA-PRAD dataset. The gene discussed is OSBP2; the disease is posterior cortical atrophy.