The DEGs in HLM regulators in different pathological T (pT) stages (187 with T2; 291 with T3; and 10 with T4) were also analyzed, and UHRF1, EZH2, ORC1, NSD2, EED, DNMT3A, KMT5C, and PRDM12 were significantly elevated in T3 stage PCa compared with T2 stage PCa (P < 0.001) (Figure 3B and Table S4). This evidence concerns the gene NSD2 and posterior cortical atrophy.