NSD2 and neoplasm: Six intersecting DEGs of EZH2, NSD2, KMT5C, UHRF1, ORC1, and DNMT3A were found in the 5 comparisons, and all were consistently highly expressed in tumor and other advanced-stage parameters (in the GS > 7, pT3, HR > 1, and TP53 mutation groups) (Figure 4A).