Being that irinotecan and topotecan are standard chemotherapy modalities used in the clinic for the treatment of recurrent or refractory NB, we specifically further explored these hits in SKNAS (11q del/MYCN wt), NGP (11q del/MNA), SH-SY5Y (11q wt/MYCN wt) and SKNBE (11q wt/MNA) cells. Here, MYCN is linked to neuroblastoma.