Additionally, it has been shown that the PI3K/Akt signal transduction pathway is closely related to tumorigenesis and development of breast cancer, and the expression levels of p-PI3K and p-Akt are increased in breast cancer cells under hypoxia, while the expression levels decrease after TBG intervention, suggesting that TBG may exert its function through the PI3K/Akt pathway and suppress the proliferation and invasion of breast cancer cells (59). The gene discussed is AKT1; the disease is breast cancer.