We also identified several genes that were co-expressed with bub1. Among them were tpx2 and ASPM. tpx2 encodes a microtubule-associated protein that is often overexpressed in other cancers (49–52) and contributes to the growth, metastasis, recurrence, and poor prognosis of liver cancer (50, 53–55). The gene discussed is TPX2; the disease is cancer.