We also identified several genes that were co-expressed with bub1. Among them were tpx2 and ASPM. tpx2 encodes a microtubule-associated protein that is often overexpressed in other cancers (49–52) and contributes to the growth, metastasis, recurrence, and poor prognosis of liver cancer (50, 53–55). This evidence concerns the gene ASPM and liver cancer.