IGF2BP3 and esophageal squamous cell carcinoma: A study by Huaying Zhao, Wei Guo and Wakita A showed that advanced ESCC patients with high levels of IGF2BP3 expression had A significantly worse prognosis than patients with low levels of IGF2BP3 expression, and IGF2BP3 expression status is an important independent prognosisative factor for patients undergoing surgical treatment alone (52, –54).