TF and hepatocellular carcinoma: In terms of TF genes, ARID2 is correlated with the initiation and progression of HCC(Schulze et al., 2015); NFE2L2 is involved in hepatocarcinogenesis and progression (Nault et al., 2014; Niu et al., 2016); HNF1A is related to promoting genetic liver adenomatosis occurrence and possibly further malignant transformation to HCC(Zucman-Rossi et al., 2015).