Moreover, a significant decrease in apolipoprotein A-I and A-II has been found in hyperprolactinemic women as compared to healthy control women (94); among these women with hyperprolactinemia, a significant decrease in apolipoprotein B has also been observed in those with high estradiol levels as compared to those with low estradiol levels (94). Here, APOA1 is linked to hyperprolactinemia.