After adjusting for BMI, SBP, DBP, FBG, FC-P, TC, TG, Cr, BUN, eGFR, hypertension percentage, use of ARB/ACEI, other antihypertensive drugs, no antihypertensive drug treatment, duration of diabetes, and insulin, we observed that urine m6A still remained independently associated with DN in model 1 and with macroalbuminuria in model 2 (Table 4). The gene discussed is INS; the disease is diabetes mellitus.