Furthermore, hypertension percentage, SBP, antihypertensives drug treatment, use of angiotensin-receptor blocker/angiotensin-converting enzyme inhibitors (ARB/ACEI), other antihypertensives drugs, and insulin, and levels of TG, Cr, and BUN were significantly elevated, while eGFR was obviously decreased in patients with DN compared with patients with T2DM (P < 0.05). The gene discussed is INS; the disease is liver dysplastic nodule.