SLC7A1 and Parkinson disease: In PD, parkin protein was shown to bind ERRs and increase their ubiquitination and degradation in vitro using cultured neuronal cell lines and in a mouse model of PD [164], on the other hand, parkin-mediated degradation of ERR is attenuated in PD patients’ fibroblasts with mutated parkin and parkin-null mice [164].