PGC-1α is also important in prolonging lifespan and protecting from metabolic diseases during aging, i, increased muscle PGC-1α protein expression was shown to promote several functions such as preserving mitochondrial activity, muscle integrity, neuromuscular junctions and inhibiting proteasomal degradation, autophagy, and apoptosis in transgenic mice [67]. The gene discussed is PPARGC1A; the disease is Other metabolic disease.