For instance, resveratrol treatment, post-induction of ischemia in rodent models, activates hippocampus astrocytes and microglia and suppresses the inflammatory response mediated by nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), cyclooxygenase-2 (COX-2), and nitric oxide synthase (NOS) in rat hippocampal cells [130]. This evidence concerns the gene PTGS2 and ischemia.