Recently, selenium-based nanoformulations of resveratrol (RSV-SeNPs) were shown to mitigate oxidative stress, neuroinflammation, and mitochondrial dysfunction by upregulating the expression of SIRT1, Aβ peptides and decreasing tau hyperphosphorylation, and reducing the levels of microRNA-134 in aluminum chloride-induced AD in rats. Here, SIRT1 is linked to Alzheimer disease.