Hypoxia induction in a steroidogenic human ovarian granulosa-like tumor cell line (KGN) resulted in the downregulation of SIRT1, PGC-1α, and mtDNA, an effect that was reversed by resveratrol through SIRT1-mediated deacetylation and activation of PGC-1α [73]. This evidence concerns the gene PPARGC1A and neoplasm.