HMGB1 and neoplasm: Among them, six genes (ELANE, IL6, NLRP1, NLRP3, CHMP7, and CHMP3) were downregulated while 23 other genes (GPX4, CHMP2A, CHMP4A, CHMP4B, CHMP4C, BAX, IL1A, TP53, TP63, NLRP2, NLRP7, PLCG1, CASP3, CASP5, CASP6, CASP8, GSDMB, GSDMD, PYCARD, BAK1, AIM2, CYCS, and HMGB1) were upregulated in the tumor group.