A more comprehensive analysis of the multi-disease regulation involved in ghrelin is warranted; for example, the epithelial–mesenchymal transition process that occurs in cardiomyocytes during cellular fibrosis caused by cardiac ischemia also occurs in tumor cell proliferation and metastasis, which is effectively ameliorated by ghrelin [134,136,137]. This evidence concerns the gene GHRL and myocardial ischemia.