VDR and hyperinsulinemic hypoglycemia, familial, 4: The present results are possibly justified by the expression of vitamin D receptors in adipocytes, which makes adipose tissue a kind of vitamin D reservoir that sequesters 25(OH)D circulating in the organism, leading to a reduction in its bioavailability and contributing to a greater risk of the development of serum 25(OH)D insufficiency and deficiency in individuals with obesity [11,12,13,14].