TJP1 and Alzheimer disease: Further analysis of permeability-related protein expression showed that abundances of colonic occludin and ZO−1 proteins were significantly lower in the ADC group (p < 0.05 or p < 0.01) compared with the WTC group and were significantly increased by exercise in the AD mice compared with mice of the ADC group (p < 0.05) (Figure 5C,D).