Our results show that serum LPS and TNF−α were significantly elevated (p < 0.01), brain LPS were significantly elevated (p < 0.01), and the abundances of blood–brain barrier proteins occludin, ZO−1, and claudin−5 were reduced (p < 0.05 or p < 0.01) in AD mice compared with wildtype mice, trends that were reversed by exercise (Figure 6A–G), which attenuated the occurrence of intestinal and cerebral leaks. This evidence concerns the gene TNF and Alzheimer disease.