Additionally, it has been well documented that adherence to hPDI is associated with lower levels of leptin, insulin, C-reactive protein, and higher levels of adiponectin in various populations [49,50,51], while inflammation and insulin resistance play a central role in the occurrence and progression of NAFLD/liver fibrosis [52,53,54,55]. This evidence concerns the gene LEP and metabolic dysfunction-associated steatotic liver disease.