INS and Insulin resistance: Neither the administration of 15 mg/kg, nor that oft 5 mg/kg (Supplementary Figure S1), of DPIN, resulted in alterations of plasma glucose (Figure 4A. However, 15 mg/kg D-Pinitol resulted in a decrease in insulin secretion (F(7,72) = 2.9, p < 0.01, Figure 4B), slightly reducing the HOMA index of insulin resistance (F(7,64) = 2.6, p < 0.05, Figure 4C).