PCDH15 and obesity due to melanocortin 4 receptor deficiency: For example, using multiple machine learning algorithms, best predictors of obesity status were identified, and included single-nucleotide polymorphisms (mapped to genes such as STXBP6, BBX, PLXDC2, PCDH15, TPH2, PCDH15, CALN1, FGF14, LRRN1, ACTBP2, RBMXP1, and ZNF32) together with differentially methylated sites (in proximity to CPT1A, ABCG1, SLC7A11, RNF145, and SREBF1 genes) and interactions with dietary factors encompassing specific foods, micronutrients, and bioactive compounds [7].