In validating the performance of screening tools for predicting RFS in neurocritically ill patients, we found that the sensitivity and positive predictive values of the SNAQ and GLIM were unsatisfactory, which may be attributed to the fact that these two screening or diagnosis tools are mainly used to identify populations that are at high risk of malnutrition or developed malnutrition without including other risk factors that closely contribute to RFS, such as alcoholism, drug use (insulin, chemotherapy, antacids, and diuretics), and decline in any electrolytes. The gene discussed is INS; the disease is malnutrition.