The absence of STING does not protect mice from steatosis or liver injury in response to FPC feeding. Given our mixed results regarding the contribution of STING to TM liver injury and high fructose feeding, we decided to investigate the role of STING in a more aggressive NASH-inducing model and thus fed mice a Fructose–Palmitate–Cholesterol (FPC) diet for varying time points. Here, STING1 is linked to metabolic dysfunction-associated steatohepatitis.