SOD1 and Insulin resistance: Moreover, hamsters fed a semipurified HF–high-cholesterol diet for 12 weeks and supplemented with a melon extract, characterized by high SOD levels, presented an improved metabolic profile in several aspects including: insulin resistance, dyslipidaemia, fat mass, atherosclerosis, steatosis, liver superoxide anion, cytochrome C activity, and lipid and protein oxidation products [17,19].