Many animal studies have suggested that vitamin D may protect against NAFLD pathogenesis and progression through several functions, including anti-inflammatory [40,41], anti-oxidant [42], anti-fibrosis [43,44], modulating intra-hepatic lipid accumulation [45], improving insulin sensitivity [46], preserving the gut homeostasis [47], and increasing intestinal absorption of bile acids [48]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.