The majority of the studies evaluating the efficacy of SCD are retrospective or case series studies conducted in the pediatric population and mainly in CD patients, and found decreased C-reactive protein (CRP), hematocrit, albumin or erythrocyte sedimentation rates (ESR), as well as an improvement in disease activity [98,99,100,101,103,104] (Table 2). This evidence concerns the gene CRP and Schnyder corneal dystrophy.