A model of adiponectin deficiency was applied in two groups of experimental colitis mice (induced by dextran sulfate sodium (DSS) and trinitrobenzene sulphonic acid (TNBS)), according to the study conducted by Fayad et al. The external stimulation of DSS-exposed mice with adiponectin caused the elevation in the synthesis of IL-6 and macrophage inflammatory protein-2 (MIP-2); it was not observed in the situation of adiponectin knockout [113]. Here, IL6 is linked to colitis.