For example, the Se-enriched Grifola frondosa polysaccharide could enhance the thymus and spleen indices of the tumor-bearing mice, increase both serum tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) levels, and also promote nitric oxide (NO) production and macrophage phagocytosis [18]. This evidence concerns the gene TNF and neoplasm.