Compared with the CK group, the mRNA expression of GPR41 was significantly upregulated, 1.5-fold in the APF group, 4-fold in the APS group, and 7-fold in the APRS group; the mRNA expression of GPR43 was upregulated about 2-fold, 4-fold, and 10-fold in APF, APS, and APRS groups, respectively. This evidence concerns the gene FFAR2 and autoimmune polyendocrinopathy.