AKT1 and Insulin resistance: Previous studies found that Pueraria polysaccharides exert a hypoglycemic effect by activating the PI3K/AKT signaling pathway [16] through the up-regulation of PI3K and AKT expressions and the down-regulation of the expressions of the FoxO1, PCK2, and G6P enzymes in insulin-resistant cells so as to improve insulin resistance in diabetes patients [17].