In that study, ambulatory adult patients with Becker muscular dystrophy, a neuromuscular genetic disorder characterized by progressive loss of contractile skeletal muscle, were administered EC for a short period of time, which elevated mitochondrial content in muscles, increased the expression of PGC-1α and biomarkers indicative of mitochondrial biogenesis, and improved exercise endurance [38]. Here, PPARGC1A is linked to Becker muscular dystrophy.