Many of the studies have also indicated that the levels of pro-inflammatory cytokines are elevated in severe dengue patients, such as interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and IL-1β, which may result in cytokine storm and increase the severity of dengue in patients [11,12,13,14]. The gene discussed is CXCL8; the disease is dengue disease.