Molecular analysis results revealed that ALS inhibits melanogenesis by regulating signaling pathways that downregulate the expression of MITF, and as a result, the expression of the genes that are under its transcriptional regulation, which includes the tyrosinase (Tyr) and tyrosinase-related protein 1 (Trp1), was decreased. This evidence concerns the gene MITF and amyotrophic lateral sclerosis.