SMC2 and amyotrophic lateral sclerosis: The genes that were highly upregulated (≥2 fold change) with 5 μg/mL ALS treatment were SMC3, SMC2, IQGAP1, RSF1, KTN1, SMC4, ANXA1, CYP1B1, LUC7L3, THBS1, ANKRD36, MYH10, CYP1B1, HIST2H2AC, NEMF, and ASMP (Table 1).