LRP1 and neoplasm: Additionally, Xin et al. [8], proved that the conjugation of ANG-2 to the surface of PEG-PCL NPs leads to LRP-1-mediated improved transport at the endothelial layer of the BBB in vitro but also to an improved accumulation in the brain parenchyma of healthy and tumor-bearing mice in vivo, proving first that the targeting ability of the peptide is independent of the presence of disrupted BBB associated to the late stages of the tumor, and second, its ability to target tumor cells.