For example, early inoculation with spore-forming Clostridium class IV and XIV species and other bacteria has been shown to lead to decreased levels of circulating IgE in adulthood while colonization of H. influenzae, S. pneumoniae, or M. catarrhalis within the first month of life increases the risk of asthma, leading to high counts of atopic markers, such as eosinophils and serum IgE [209,210,211]. The gene discussed is IGHE; the disease is asthma.