IGHE and allergic disease: Thus, the most important mechanisms in suppressing an allergic reaction could be based on modulating TLR and proteins that recognize enterocyte proteoglycans, leading to DC activation and Th1 response, stimulation of the Th1 cytokine and suppression of the Th2 response, increased IFN-γ production and decreased IgE and antigen-induced TNF-α, IL-5 and IL-10 secretion.