GSR and Irritability: The antioxidant properties of propolis and flavonoids and their ability to increase the activity of antioxidant enzymes is essential in reducing ROS and oxidative stress and consequently reducing bronchoconstriction and airway hyperreactivity [66,67,120,136,166,167,168], and establishing tissue homeostasis via increased activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and GSH [168].