Increased levels of blood markers of activated platelets (PF4, P-selectin, β-thromboglobulin (β-TG), and PMP) have been observed in numerous human diseases, including systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and small vessel vasculitis, AD and psoriasis, but also in a mouse model of AD. This evidence concerns the gene PF4 and systemic sclerosis.