Members of the S100 family of proteins intensively studied in the course of psoriasis include S100A4 (Figure A1), S100A7 (Figure A2), S100A8 (Figure A3), S100A9 (Figure A4), S100A12 (Figure A5), S100B (Figure A6) and S100A15, indicating their involvement in the pathogenesis of the disease [1,16,17,18,19,22,24,194,199,200]. The gene discussed is S100B; the disease is psoriasis.