These abilities may be due to the inhibition of COX-2 mediators and NF-κB transcription factor and reciprocally regulated MMP-2- and MMP-9-signaling pathways; however, additional studies are needed to clarify the cross-talk between the Cal among inflammatory cytokines and metastatic markers in different colon cancer cell lines. This evidence concerns the gene MMP2 and malignant colon neoplasm.