In addition, several HHC-related machaeriol analogs were synthesized, showing a strong inhibition of tumor (breast cancer) growth by targeting VEGF-mediated angiogenesis signaling in endothelial cells and suppressing VEGF production and cancer cell growth [29]; however, to best of our knowledge, machaeridiol analogs have not been synthesized and reported for anti-MRSA or anticancer activities. Here, VEGFA is linked to breast cancer.