INS and metabolic syndrome: For example, cyanidin-3-O-glucoside supplementation increases the expression of Peroxisome Proliferator-Activated Receptors (PPARs), thus reducing dyslipidemia and increasing sensitivity to insulin in mice after eight weeks of supplementation by increasing lipid oxidation [98] and plays a role to retrieve IR in diabetes by re-establishing insulin secretion and decreasing IL-1β and IL-6 concentrations [99].