Chen et al. demonstrated the binding of miR-200 homologs to the 3’UTR region of PTEN in endometrial cancer cells using a luciferase assay, and the importance of E2 in regulating miR-200c expression was also demonstrated via ERα overexpression, which is important for the development of this type of cancer [65]. The gene discussed is PTEN; the disease is endometrial cancer.