The decrease in cell viability as well as the recovery of ERβ gene expression on HT-29 cells under treatment with naringenin and its extract FEN suggest that the expression of this receptor is associated with apoptotic mechanisms and DNA damage repair, although the increase in ERα gene expression related to proliferation processes, increased ERβ expression plays a very important role in inhibiting colon cancer development. Here, ESR2 is linked to malignant colon neoplasm.