ANXA5 and breast carcinoma: The toad skin extract cinobufatini inhibited migration of human breast carcinoma MDA-MB-231 cells in a model stromal tissue [118], while key members of bufadienolides, i.e., BF, bufotalin, and gamabufotalin, have significantly sensitized human breast cancer cells with different status of ER-α to apoptosis induction of TRAIL, as evidenced by enhanced Annexin V/FITC positive cells (apoptotic cells), cytoplasmic histone-associated DNA fragments, membrane permeability transition (MPT), caspases activation, and PARP cleavage [119].